INHIBITION OF PROTEIN GLYCATION AND PREVENTION OF

专利名称：INHIBITION OF PROTEIN GLYCATION AND

PREVENTION OF VASCULOPATHY

发明人：COHEN, MARGO, P.,CLEMENTS, REX申请号：EP97906922申请日：19970219公开号：EP0946170A4公开日：20020320

摘要：The present invention is directed to preventing the nonenzymatic glycation ofalbumin, which generates biologically active Amadori glucose adducts in the albuminmolecule, as well as methods of using compounds that protect albumin againstnonenzymatic glycation to prevent vasculopathy. The present invention also is directedto preventing the nonenzymatic glycation of apolipoprotein B in low density lipoproteins,which generates Amadori glucose adducts in the apo B molecule that predispose to lipidoxidation and to LDL-cholesterol internalization leading to foam cells, as well as methodsof using compounds that protect apo B/LDL against nonenzymatic glycation to preventatherosclerosis and to reduce serum cholesterol levels.

申请人：EXOCELL, INC.

更多信息请下载全文后查看