专利名称：Antisense oligonucleotides
发明人：Uttam Surana,Dave Keng Boon Wee,Jing
Lin,Bing Lim
申请号：US16345487申请日：20171016公开号：US11072795B2公开日：20210727
摘要：The present invention relates to antisense oligonucleotides for modulating theactivity of glycine decarboxylase (GLDC). In particular, the present invention relates toantisense oligonucleotides capable of inducing exon skipping of RNA. Also claimed arepharmaceutical compositions, kits and methods of treating cancer and inducing exon-skipping using said antisense oligonucleotides. In addition, a method for aiding thecategorising or determining prognosis of a cancer or in selecting a therapeutic strategyfor a patient with cancer, based on assessing the level of GLDC nucleic acid, protein oractivity in a sample derived from the patient is provided.
申请人：AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
地址：Singapore SG
国籍：SG
代理机构：Troutman Pepper Hamilton Sanders LLP
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