专利名称：DIFFERENTIATED CELLS SUITABLE FOR
HUMAN THERAPY
发明人：GOLD, Joseph, D.,LEBROWSKI, Jane, S.申请号：EP01986488.3申请日：20011126公开号：EP1337632A2公开日：20030827
摘要：This invention provides a system for producing differentiated cells from a stemcell population for use wherever a relatively homogenous cell population is desirable.The cells contain an effector gene under control of a transcriptional control element(such as the TERT promoter) that causes the gene to be expressed in relativelyundifferentiated cells in the population. Expression of the effector gene results indepletion of undifferentiated cells, or expression of a marker that can be used to removethem later. Suitable effector sequences encode a toxin, a protein that induces apoptosis,a cell-surface antigen, or an enzyme (such as thymidine kinase) that converts a prodruginto a substance that is lethal to the cell. The differentiated cell populations producedaccording to this disclosure are suitable for use in tissue regeneration, and non-therapeutic applications such as drug screening.
申请人：Geron Corporation
地址：230 Constitution Drive Menlo Park, CA 94025 US
国籍：US
代理机构：Bassil, Nicholas Charles
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