Nf-kb activation inhibitors

专利名称：Nf-kb activation inhibitors发明人：Susumu Muto,Akiko Itai申请号：US10516294申请日：20030605

公开号：US20060089395A1公开日：20060427

摘要： A medicament having inhibitory activity against NF-κB activation whichcomprises as an active ingredient a substance selected from the group consisting of acompound represented by the following general formula (I) and a pharmacologicallyacceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A

represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group whichmay be substituted, provided that the compound wherein said heteroaryl group is {circlearound (1)} a fused polycyclic heteroaryl group wherein the ring which binds directly to —CONH— group in the formula (I) is a benzene ring, {circle around (2)} unsubstitutedthiazol-2-yl group, or {circle around (3)} unsubstituted benzothiazol-2-yl group is

excluded, ring Z represents an arene which may have one or more substituents in additionto the group represented by formula —O-A wherein A has the same meaning as thatdefined above and the group represented by formula —CONH-E wherein E has the samemeaning as that defined above, or a heteroarene which may have one or more

substituents in addition to the group represented by formula —O-A wherein A has thesame meaning as that defined above and the group represented by formula —CONH-Ewherein E has the same meaning as that defined above.

申请人：Susumu Muto,Akiko Itai

地址：Tokyo JP,Tokyo JP

国籍：JP,JP

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