Processes and synthetic intermediates for preparin

专利名称：Processes and synthetic intermediates for

preparing N-arylacridancarboxylic acidderivatives

发明人：Hashem Akhavan-Tafti,Robert A.

Eickholt,Richard S. Handley

申请号：US09770015申请日：20010125

公开号：US20010031869A1公开日：20011018

摘要：Synthetic processes and intermediates are disclosed for the preparation of N-arylacridancarboxylic acid derivatives. The derivatives are esters, thioesters, amides andsulfonimides. A key feature of the processes is the preparation of N-aryl substitutedintermendiates by formation of a bond between the nitrogen atom of the acridan ringand a carbon atom of another aromatic or heteroaromatic ring compound. The arylationreaction is catalyzed by a palladium catalyst. The N-arylacridancarboxylic acid derivativesare useful in methods for producing light and in assays for peroxidase enzymes andenzyme inhibitors and in assays employing enzyme-labeled specific binding pairs.

申请人：AKHAVAN-TAFTI HASHEM,EICKHOLT ROBERT A.,HANDLEY RICHARD S.

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