专利名称：Detection of Genomic Rearrangements by
Sequence Capture
发明人：Michael RUVOLO,Emily Marine LEPROUST申请号：US14772064申请日：20130305
公开号：US20160017425A1公开日：20160121
摘要：Provided herein is a method of sample analysis. In some embodiments, themethod comprises hybridizing fragmented genomic DNA from a test genome with apopulation of first oligonucleotides of the formula V-B-Vin the presence of one or moresecond oligonucleotides; contacting the product with ligase to join the ends of thefragmented genomic DNA that are hybridized to Vand Vto the one or more secondoligonucleotides; and subjecting the product to polymerase chain reaction conditionsusing amplification primers that hybridize to sites that are provided by the one or moresecond oligonucleotides, wherein production of a product indicates that the test genomecontains a chromosomal rearrangement relative to the reference genome.
申请人：AGILENT TECHNOLOGIES, INC.
地址：Santa Clara, CA US
国籍：US
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