SPIRO COMPOUNDS, MEDICINAL COMPOSITIONS CONTAINING

专利名称：SPIRO COMPOUNDS, MEDICINAL

COMPOSITIONS CONTAINING THE SAMEAND INTERMEDIATES OF THE COMPOUNDS

发明人：WATANABE, NOBUHIDE,NAKAGAWA,

HIROSHI,TSUJI, JUN-ICHI,MINATO,

HISAO,IKENO, AKIHISA,KOHAYAKAWA, CHIE

申请号：EP03717627申请日：20030417公开号：EP1559707A4公开日：20060802

摘要：A spiro compound represented by the following formula (I) wherein R<1> andR<2> are the same or different and each is a hydrogen atom, a chlorine atom and thelike, n is 1, 2 or 3, a bond containing a broken line is a single bond or a double bond, A is -X-(CH2)q-N(R<3>)(R<4>); a group represented by the following formula (a) and the like,wherein X is an oxygen atom or a sulfur atom, q is 2 or 3, R<3> and R<4> are the same ordifferent and each is a C1-6 alkyl group and the like, or R<3> and R<4> optionally form,together with the adjacent nitrogen atom, a piperidine ring and the like optionallysubstituted by one or two C1-6 alkyl and the like, R<5> is a C1-6 alkyl group and the like,R<6> is a hydrogen atom and the like, and r and t are each independently one or two, ora pharmaceutically acceptable acid addition salt thereof. The compound is useful as aselective estrogen receptor modulator having a climacteric syndrome-amelioratingeffect, and can be expected to be a drug for the prophylaxis and/or treatment ofosteoporosis, climacteric syndrome and breast cancer.

申请人：DAINIPPON PHARMACEUTICAL CO., LTD.

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