METHODS AND COMPOSITIONS FOR PREDICTING RESISTANCE

专利名称：METHODS AND COMPOSITIONS FOR

PREDICTING RESISTANCE TO ANTICANCERTREATMENT WITH PROTEIN KINASEINHIBITORS

发明人：BERNARDS, Rene,HUANG, Sidong,HOLZEL,

Michael

申请号：EP12716857.3申请日：20120404公开号：EP2694677A2公开日：20140212

摘要：The instant application provides methods and related compositions pertainingto the identification of resistance to anticancer treatment in a patient. In a particularembodiment, the invention provides biomarkers for the identification of resistance toanticancer treatment in a lung cancer patient, wherein a reduced expression of aMEDIATOR and/or SW1/SNF complex gene in the lung cancer cells of the patientindicates that the lung cancer cells in the patient may be resistant to treatment with areceptor tyrosine kinase inhibitor, such as gefitinib and/or erlotinib. In some

embodiments, the invention relates to methods and related compositions for predictingresistance to anticancer treatment by detecting the expression levels of one or moreTGF-beta pathway nucleic acids and/or proteins.

申请人：Netherland Cancer Institute

地址：Plesmanlaan 121 1066 CX Amsterdam NL

国籍：NL

代理机构：EP&C

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