专利名称：Cholinergic modulation of microglial
activation via alpha-7 nicotinic receptors
发明人：Doug Shytle,Jun Tah,Paul R. Sanberg申请号：US11349455申请日：20060207
公开号：US20060142180A1公开日：20060629
摘要：Novel therapeutic targets in the treatment of neuroimmunological andneurodegenerative disorders. Accordingly, methods of treating a neurodegenerativedisorder in a patient, as well as inhibiting the release of a proinflammatory cytokine,comprising the step of contacting a target cell with a therapeutically effective amount ofa cholinergic agonist, such as those chosen from the group consisting of acetycholine,nicotine, choline, galantamine, cytisine, GTS-21, or derivatives thereof, wherein the targetcell is a microglia is provided.
申请人：Doug Shytle,Jun Tah,Paul R. Sanberg
地址：Lutz FL US,Tampa FL US,Spring Hill FL US
国籍：US,US,US
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