Substituted pharmacologically acitve imidazole der

专利名称：Substituted pharmacologically acitve

imidazole derivatives and their preparationand use

发明人：Kurkela, Kauko Oiva Antero,Karjalainen, Arto

Johannes

申请号：EP82306295.5申请日：19821125公开号：EP0081324A2公开日：19830615

摘要：The invention provides novel compounds of the formula: or wherein each of R, Rand R, which can be the same or different, is hydrogen, chloro, bromo, fluoro, methyl,ethyl, methoxy, amino, hydroxy or nitro; R is hydrogen or alkyl of 1 to 7 carbon atoms; Ris hydrogen or a straight or branched alkyl group of 1 to 5 carbon atoms or a phenylgroup; R is hydrogen or an alkyl group of 1 to 7 carbon atoms or a substituted orunsubstituted benzyl group; and n is 0 or 1; provided that when R, R, R, R and R are allhydrogen and R, is and their non-toxic pharmaceutically acceptable acid addition salts.Processes for the preparation of these compounds are described, as are novel

pharmaceutical compositions comprising the compounds or their salts. These compoundsexhibit valuable pharmacological activity and are useful in the treatment of mammals, e.g.as diuretic agents. Furthermore, they have antithrombotic and anti-hypertensive effects.

申请人：Farmos Group Ltd.

地址：Tengströminkatu 6 P.O. Box 425 SF-20101 Turku 10 FI

国籍：FI

代理机构：Collier, Jeremy Austin Grey (GB)

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