专利名称：Method of inhibiting the transcription of
genes
发明人：PATRICK BAEUERLE,THOMAS HENKEL申请号：AU6538094申请日：19940331公开号：AU691492B2公开日：19980521
摘要：PCT No. PCT/EP94/01014 Sec. 371 Date Jan. 22, 1996 Sec. 102(e) Date Jan. 22,1996 PCT Filed Mar. 31, 1994 PCT Pub. No. WO94/23045 PCT Pub. Date Oct. 13,1994Inhibition of the transcription of genes in higher eukaryotic cells by inhibiting theactivation of NF-KB, wherein the cells are treated with substances which specifically inhibitthe proteolytic degradation of IKB- alpha directly or indirectly. Process for screeningsubstances which inhibit NF-KB activation by inhibiting the proteolytic degradation of IKB-alpha . Use of the substances for treating pathological conditions which can be tracedback to undesirable gene expression controlled by NF-KB.
申请人：BOEHRINGER INGELHEIM INTERNATIONAL GMBH
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