2-Amino-1,4-dihydropyridine derivatives

专利名称：2-Amino-1,4-dihydropyridine derivatives发明人：MEYER; HORST,BOSSERT; FRIEDRICH,VATER;

WULF,STOEPEL; KURT

申请号：US33663973申请日：19730228公开号：US3867393A公开日：19750218

摘要：2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position andbeing optionally substituted by lower alkyl or phenyl in the 6-position, and thecorresponding 2-amino-1,4,5,6,7,8-hexahydro-5-oxoquinolines, which derivatives arefurther substituted by a carbonyl group in the 3-position and optionally substituted inthe 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group areantihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is arepresentative embodiment, are prepared through condensation of anylideneacetoacetic acid ester and an amidine.

申请人：MEYER; HORST,BOSSERT; FRIEDRICH,VATER; WULF,STOEPEL; KURT

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